Mitochondrial-derived peptide
MOTS-c
A signal from the mitochondria themselves.
A peptide encoded in mitochondrial DNA, studied for metabolic regulation, insulin sensitivity and exercise capacity.
- Third-party tested
- Discreet packaging
- Tracked shipping
- Answered by a person
What this actually is
Before you decide, understand it.
Mechanism
Activates AMPK signalling, supporting glucose utilisation, metabolic flexibility and mitochondrial efficiency.
MOTS-c is genuinely unusual: it is encoded not in the cell nucleus but in mitochondrial DNA, making it one of a small set of peptides the mitochondria produce to communicate with the rest of the cell. Research associates it with improved insulin sensitivity, metabolic flexibility, and exercise capacity — and levels decline with age, as with most things in this category.
It is the compound to look at if the goal is metabolic health rather than weight specifically.
What to expect, and when
Timelines are compound-specific. Here's this one's.
Week 1–2
Exercise capacity and recovery between sessions.
Week 4–8
Metabolic markers, for anyone actually testing them.
Good to know
The things we'd tell you in person.
- 01
Encoded in mitochondrial DNA rather than nuclear DNA — genuinely uncommon.
- 02
The effect is most apparent in people who are training.
- 03
Often paired with NAD+ on the shared mitochondrial rationale.
Order together
What people order alongside MOTS-c.
Before you order
Common questions.
Anything not covered here, ask us directly — English or Spanish.
Ask about MOTS-c →Peptides ship as a freeze-dried powder because they are far more stable that way. Reconstitution is adding bacteriostatic water to turn that powder into a measurable liquid. It matters because the ratio you choose determines what every subsequent dose actually contains — get the ratio wrong and every dose after it is wrong too. Our reconstitution kit includes a chart so you are not doing the arithmetic yourself.
Unopened lyophilised vials are stable at room temperature, away from light. Once reconstituted, refrigerate — and write the date on the vial, because you will not remember it. Do not freeze a reconstituted vial. Do not shake one; swirl it gently.
It depends on the compound. GLP-1 compounds change appetite within a week or two. Collagen-signalling peptides need six to ten weeks because new collagen has to physically be built. Recovery compounds usually show up around week three. Every product page on this site has its own timeline for exactly this reason.
No. Our products are sold as research compounds, which is why every vial is labelled for research use and why nothing on this site is presented as medical treatment. Deciding whether something is appropriate for you sits with you and whoever advises you.
You choose how to pay while you check out — Zelle, Cash App or Venmo — and the details appear the moment you place the order, along with your order number. No cards, and no card details are collected anywhere on this site. Put that order number in the payment note: it is the only thing linking your payment to your order. Every order is confirmed personally, and once a C.N.M Agent has seen the payment it moves to fulfilment with a tracking number.
Unopened, unused items in original packaging can be returned within 14 days of delivery. For safety reasons we cannot accept returns on anything that has been opened or reconstituted. If something arrives damaged or wrong, tell us and we will replace it.