GLP-1 / GIP / glucagon triple agonist
Retatrutide
Three receptors, one compound.
A triple agonist adding glucagon receptor activity to the GLP-1 and GIP mechanism, targeting energy expenditure alongside appetite.
Dose
- Third-party tested
- Discreet packaging
- Tracked shipping
- Answered by a person
What this actually is
Before you decide, understand it.
Mechanism
Adds glucagon receptor agonism to dual GIP/GLP-1 activity, associated with increased energy expenditure and mobilisation of hepatic fat.
Retatrutide is the newest of the three and the most ambitious in design. Alongside the GLP-1 and GIP activity that tirzepatide has, it adds glucagon receptor agonism — which, counterintuitively, is associated with increased energy expenditure and hepatic fat mobilisation rather than the blood-sugar rise the word 'glucagon' might suggest.
Because it is newer, the body of research behind it is smaller. We list it because people ask for it and because the early data is genuinely interesting, not because it is a drop-in upgrade.
What to expect, and when
Timelines are compound-specific. Here's this one's.
Week 1–2
Appetite changes comparable to other GLP-1 compounds.
Week 3–8
Energy expenditure effects are where this diverges from tirzepatide.
Month 3+
Longer-horizon data is still emerging. Conservative titration is the sensible default.
Good to know
The things we'd tell you in person.
- 01
Newer than tirzepatide, with a correspondingly smaller research base.
- 02
Titrate more conservatively than you would with a compound you already tolerate.
- 03
Not a starting point for a first-time user in our view — most people should not begin here.
A GLP-1 protocol's first 90 days
What actually happens month by month, what to eat, and the mistake that costs most women their lean mass.
Read the guide →Order together
What people order alongside Retatrutide.
Before you order
Common questions.
Anything not covered here, ask us directly — English or Spanish.
Ask about Retatrutide →Peptides ship as a freeze-dried powder because they are far more stable that way. Reconstitution is adding bacteriostatic water to turn that powder into a measurable liquid. It matters because the ratio you choose determines what every subsequent dose actually contains — get the ratio wrong and every dose after it is wrong too. Our reconstitution kit includes a chart so you are not doing the arithmetic yourself.
Unopened lyophilised vials are stable at room temperature, away from light. Once reconstituted, refrigerate — and write the date on the vial, because you will not remember it. Do not freeze a reconstituted vial. Do not shake one; swirl it gently.
It depends on the compound. GLP-1 compounds change appetite within a week or two. Collagen-signalling peptides need six to ten weeks because new collagen has to physically be built. Recovery compounds usually show up around week three. Every product page on this site has its own timeline for exactly this reason.
No. Our products are sold as research compounds, which is why every vial is labelled for research use and why nothing on this site is presented as medical treatment. Deciding whether something is appropriate for you sits with you and whoever advises you.
You choose how to pay while you check out — Zelle, Cash App or Venmo — and the details appear the moment you place the order, along with your order number. No cards, and no card details are collected anywhere on this site. Put that order number in the payment note: it is the only thing linking your payment to your order. Every order is confirmed personally, and once a C.N.M Agent has seen the payment it moves to fulfilment with a tracking number.
Unopened, unused items in original packaging can be returned within 14 days of delivery. For safety reasons we cannot accept returns on anything that has been opened or reconstituted. If something arrives damaged or wrong, tell us and we will replace it.